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The nasal route bypasses enzymatic breakdown in the digestive system and avoids the hepatic first-pass effect, making it particularly attractive for compounds with delicate molecular structures like peptides

[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils

Some pharmacies report stability data supporting up to 60 days at controlled room temperature

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