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In a mouse model of cerebral ischemia, HCA2 activation by BHB promotes a neuroprotective phenotype of macrophages to produce prostaglandin D2, which exerts neuroprotective effects, suggesting a potential immunomodulatory mechanism that may be relevant in inflammatory contexts [45]

The intra-cellular distribution and functions of H 2 O 2 are still not completely clear, and more experimentation is required to determine whether the chloroplasts, mitochondria, peroxisomes, and cytosol H 2 O 2 pools fulfill different roles and how they are inter-connected

AI-guided drug discovery has emerged as a transformative strategy in designing potent small-molecule inhibitors against these targets, optimizing them for both efficacy and pharmacokinetic profiles 121,124,138

[778] Across the nine SAFER Guides and 165 recommendations within them, the estimated time to complete all nine self-assessments would range from a minimum of 4.5 hours to a maximum of 55 hours

The first clinical trial will be carried out to investigate the safety and efficacy of AstroStem, a novel treatment modality comprising AD-MSCs, in AD patients using a double-blind randomized control test

The co-delivery of mTHPC and BU using nanoparticles effectively increased the therapeutic efficacy of PDT by suppressing the SRC-3/HIF-1 pathway in CRC
