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For knocking out a target gene, 2-4 sgRNAs were injected along with co-injection markers
No changes were seen in the PLC2 core that would be consistent with this model
While the origins of the observed differences between mice and humans with respect to the l-carnitineBBTMATMAO pathway are not clear, the fact that the second reaction in the conversion of l-carnitine into TMA (i.e., BBTMA) showed marked induction with dietary exposure in subjects likely plays a major role in the observed differences
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10.1016/0022-3999(93)90104-N 136 SchwidS
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