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Secondary osteoporosis: obesity, diabetes, long-term sedentary, hormone drugs, excessive fat reduction, etc., interfere with calcium and phosphorus metabolism, inhibit osteogenesis, promote osteoclasis, and cause bone loss

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Evidence for these combinations remains limited to case reports and small case series, but interest is growing

Structural rebuilding depends on: Adequate blood flow so repair materials can reach the site Proper cellular migration so rebuilding is organized Inflammation control so tissue is not continually degraded When GHK-Cu is used alone, you may see improvements in texture and appearance, yet deeper functional recovery can lag when the rest of the repair system is not supported