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Consistent with these results, IR-induced phosphorylation of ATM was dramatically suppressed in the PXR-KO cells where the ATF3 expression level was downregulated ( Figure 6A , lanes 610 vs

In addition, we also observed lower expression of BAX and caspase 3 and higher expression of Bcl-2 in hyperplastic prostate tissues compared with normal prostate tissues, which showed that with the down-regulation of GPX3, the apoptosis level of hyperplastic prostate was inhibited at the tissue level

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