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The complex travels through the small intestine until it reaches the terminal ileum, where specialised receptors called cubam (a complex of cubilin and amnionless proteins) recognise and facilitate the uptake of the B12-IF complex into enterocytes (intestinal cells)

All on/off effect occurrences responded to L-tyrosine dosing optimization

doi: 10.1210/jc.2008-2385 98 PriyadarsiniNRamachandranMBeheraKKKiranSDeviS

PLoS ONE 8(3):e59119

A study on mice with a triple knockout of CBS, CSE, and 3-MST supported this notion, revealing that supersulfides are still produced in the absence of these enzymes, further indicating the presence of compensatory or alternative mechanisms [40]
