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In Phase 2 trial settings, participants have shown gradual but meaningful reductions in body weight over several months, alongside improvements in blood glucose control, blood pressure, and metabolic markers

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[DOI] [PMC free article] [PubMed] [Google Scholar] 2.From the incretin concept and the discovery of GLP-1 to today's diabetes therapy

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Mechanism of Action Blocks Angiotensin II type 1 (AT) receptors Effects: Vasoconstriction Aldosterone secretion Blood pressure Sodium & water retention Protects heart and kidneys It does not inhibit ACE, so no bradykinin buildup less cough and angioedema compared to ACE inhibitors