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The extracellular region of Met is composed of three domains: the Sema domain (homologous to the Sema domain of the semaphorins and plexins) that includes the entire chain and part of the chain

Remarkably, the core motifs of CesA_C2 show a relatively high homology to the second C domain in Vlm1 of the valinomycin NRPS although the overall similarities between the two NRPS is low (approx