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see Vitamin B12 Health Professional Fact Sheet

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When NNMT is overactive, it depletes NAD+ stores and slows metabolic rate in fat cells

Oral B12 supplements have to survive your stomach acid and get absorbed through your gut lining first

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(2021) Effects of vitamin B12 supplementation on cognitive function, depressive symptoms, and fatigue: a systematic review, meta-analysis, and meta-regression
