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doi: 10.1126/sciadv.abd0515 49 DanksLKomatsuNGuerriniMMSawaSArmakaMKolliasGet al

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Some challenges that need to be tackled are, for example, the search for the molecular mechanisms that balance the consumption of G6P between the PPP and glycolysis, the potential qualitative and quantitative differences in PPP between specific astrocytes and neuronal subtypes across different brain regions, and the involvement of PPP in the etiology and/or progression of neurodegenerative disorders

If your levels aren't improving with supplementation, discuss potential underlying health conditions, such as GI disorders, and potential medication interactions (such as antibiotics, H2 blockers, and PPIs), with your doctor