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Following birth, microbial colonization of the infants gut progresses rapidly, fueled by exposure to a diverse array of sources

Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma

doi:10.1016/0168-9452(86)90016-6

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ClinicalTrials.gov identifier: NCT01419691

Because there is a lack of experimentation on dose-response relationships within this AOP, we propose that it is a qualitative AOP