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Nature Chemical Biology 9(5):300-306

The molecular mechanisms underlying 5-amino-1MQ's anti-adipogenic effects involve complex interactions between NAD+ metabolism, methylation status, and transcriptional regulation

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5Amino1MQ inhibits NNMT, restores NAD+, boosts fat metabolism, and rejuvenates aging muscle cells, unlocking new paths for metabolism and longevity.

Additionally, Parasutterella relative abundance, which was increased in both the vehicle- and NNMTi-treated LD-switched groups relative to the controls, significantly correlated with several adipose tissue metabolites abundances

A., et al