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Ultimately, these molecular and systemic changes catalyze a profound remodeling of key brain circuits, including hippocampal impairment, limbic hyperexcitability, and a weakening of prefrontal cortical modulation
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Restoring the phenotype of fragile X syndrome: insight from the mouse model
J Clin Psychiatry 61(Suppl 11):4650 Lustberg L, Reynolds CF (2000) Depression and insomnia: questions of cause and effect
4e, Supplementary Fig
