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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Hofkens W., Schelbergen R., Storm G., Van Den Berg W.B., Van Lent P.L

The most common oneC677T polymorphism, which is present in 1012% of population (Gilbody et al., 2007), contributes to the expression of a thermolabile variant of MTHFR

This process is self-reinforcing: inflammation-derived oxidative stress promotes further ferroptosis, while dying ferroptotic cells release DAMPs that activate surrounding structural and immune cells, intensifying the inflammatory response ( 6.2 Classical and non-classical pathways of ferroptosis regulation The regulation of ferroptosis in the asthmatic airway involves both canonical and alternative mechanisms that determine cellular susceptibility to this form of cell death

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