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Interestingly, reactivation of AKT/mTOR signaling by using small molecule PI3K antagonists activates the transport of energy-active mitochondria to the cortical cytoskeleton of cancer cells, therefore heightening tumor cell invasion (202)

2017;37:BSR20160244

2-Oxatricyclo [4.3.1.0(3,8)] decane exhibited a free energy of binding of 4.15 kcal/mol, suggesting a moderate binding affinity with the MexAB-OprM efflux pump.The inhibition constant (Ki) was determined to be 906.56 m, indicating a moderate inhibitory activity against the MexAB-OprM efflux pump

Together, these mechanisms likely underlie the improved cytocompatibility observed with the CF-CA combination and support the potential of this formulation for safer topical application

Stem Cells (2009) 27:205968