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(iii) whether CoQ10 could be administered via alternative routes

proton magnetic resonance spectroscopy (MRS) may show decreased peaks of N-acetylaspartate and inositol, as well as increased levels of glutamine, reflecting the neurologic effects of hyperammonemia [13]

Subcutaneous injections are limited to 1.5 mL per site to avoid tissue distension and unpredictable absorption, while intramuscular volume limits vary by muscle group deltoid accepts up to 1 mL, vastus lateralis up to 3 mL, and ventrogluteal up to 3 mL

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Testoni, G

These variations can significantly alter key molecular characteristics such as hydrophobicity (e.g., through alkyl or terpene chains), lipophilicity (facilitating penetration of bacterial lipid membranes), planarity (as seen in aromatic systems that enable intercalation into nucleic acids), and charge distribution (e.g., the presence of cationic moieties enhancing electrostatic interaction with negatively charged bacterial surfaces) [114118]