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In this context, upregulation of VCAM-1 and integrin 4 expression in tumor-associated LECs, due to the presence of tumor-derived inflammatory factors, leads to weakened LEC junctions, further contributing to increased lymphatic permeability and cancer cell penetration into LVs (157) ( Figure 4A )

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doi: 10.1016/j.cub.2020.08.044 60 ChenJLevyATianALHuangXCaiGFidelleMet al

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