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For a compound you are injecting into your body, that gap is not trivial

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Recommended daily intake of vitamin B12 for adults : Complete guide Recommended daily intake of vitamin B12 for adults : Complete guide Daily glutathione intake can vary according to age, gender, state of health and level of environmental stress

But there is a grey/intermediary zone that exists (148-500 pmol/L ish), where patients may be deficient on a cellular level (in energy cycle and methylation) and wildly symptomatic including overt bilateral neurological symptoms, cognitive symptoms, severe fatigue (usually in the absence of anaemia) etc