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Therefore, further rigorous in vivo studies and high-quality clinical trials are essential to validate its therapeutic potential and clarify its mechanism of action

In our opinion, the association between metabolic disorders and zinc status is mainly mediated by inflammation, oxidative stress, modulation of zinc transporters, and altered lipid and glucose metabolism

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Given that most common heteroplasmies showed maternal transmission (Extended Data Fig

A notable example is Ref-1, a DNA-repair endonuclease whose activity is dependent on reduction by TRX

A growing body of evidence suggests that oxidative stress and redox dysfunction play a crucial role in the vulnerability of DA cells to harmful events within the brain and may be involved in the pathophysiology of PD [132]