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10.1111/tpj.14517 [DOI] [PubMed] [Google Scholar] 19.Li F, Dong C, Yang T, Ma J, Zhang S, Wei C, et al
12,17,6369 APAP protein adducts that form upon NAPQI conjugation with protein sulfhydryl groups of cysteine in GSH or cellular proteins readily interact with mitochondria
In BV2 microglial cell lines subjected to lipopolysaccharide (LPS)-induced neuroinflammation, both lactylation-mediated inhibition of p53 activity and direct knockdown of p53 protein can disrupt the control of the NF-B inflammatory signaling pathway, ultimately leading to abnormal expression of pro-inflammatory factors and M1 polarization of microglia [132]
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Once phosphorylated, these proteins play significant roles in DNA replication, recombination, metabolism, and cell cycle regulation
doi: 10.1002/14651858.CD005496.pub6 399 FanYLiuYShaoCJiangCWuLXiaoJet al
