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doi: 10.1016/j.ebiom.2018.12.003

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Moreover, there is a strong association between the level of soluble oligomeric A, and the severity of synaptic loss and cognitive dysfunction in AD when compared to their fibrillar counterpart (Lesne, 2014

Bile acids and microbiota: multifaceted and versatile regulators of the liver-gut axis

The mitochondrial membrane potential of protein is related to mPTP, In the early stage of apoptosis, mPTP can allow molecules with relative molecular weight less than 1.5 10 3 kDa to pass through, which leads to the decrease of mitochondrial membrane potential, the increase of mitochondrial membrane permeability and the release of pro-apoptotic proteins, which leads to apoptosis (Fall and Bennett, 1999)

Since ancient times, pineapple as the main source of bromelain has been widely applied against inflammation disorders (34)