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Prolonged stimulation of GH and IGF-1 secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults

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At a molecular level, TAC markedly increased the expression of inflammatory and fibrotic cytokines in the kidney, induced oxidative stress, and led to mitochondrial dysfunction and programmed cell death through activation of PI3K/AKT and inhibition of PTEN