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Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits

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In addition, another study also found a high concentration of the drug in the caudal medulla after intranasal administration, demonstrating that drugs can be delivered via the trigeminal pathway after intranasal administration ( 2.2.3 Vascular pathways Blood from the branches of the maxillary, facial, and ophthalmic arteries and the carotid artery supplies the nasal cavity (Patel, 2017), and drugs delivered through this pathway mainly act on the respiratory epithelial area, which has a large surface area and abundant blood vessels (Lofts et al., 2022)