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The promoter regions encoding GSTs and GCL possess binding sites for transcriptional regulators such as NF-kB, AP-1, AP-2, and the Nrf2/Kelch-like ECH-associated protein 1 (Keap1) system

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Patients may experience persistent fatigue, respiratory distress, skin issues, or neurological symptoms like brain fog and mood changes

(1977) Mutagenic activity of major mammalian metabolites of cyclophosphamide toward several genes of Escherichia coli

These articles report KEs such as oxidative stress (e.g., reactive oxygen species), DNA damage (e.g., strand breaks, oxidative lesions, DNA adducts), and altered genes frequently associated with lung tumorigenesis, such as TP53, KRAS, and EGFR