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While the precise mechanism underlying CD38 upregulation in these pathological conditions and disease models are not fully understood, CD38-mediated NAD + consumption leading to NAD + decline and consequent loss of cellular sirtuin activity appears to be a universal mechanism underlying their pathogenesis 24,31

[DOI] [PMC free article] [PubMed] [Google Scholar] 163.Heilbronn LK, de Jonge L, Frisard MI, et al

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Immunol 20, 5063 (2019)