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Too little B12 causes low energy and poor health
Factors such as initial B12 levels, underlying medical conditions, certain medications, advanced age, and injection frequency can affect the absorption and utilization of B12, possibly shortening the duration of action

These findings are somewhat misleading and not all that applicable to human longevity

Vitamin B12 is almost exclusively found in animal-derived food stuffs fish, meat, dairy, and eggs
ICD-10-CM Code Set (FY2026) All codes verified against the FY2026 ICD-10-CM Tabular List and Index (CMS.gov) effective October 1, 2025

After that first period, any signs that you are moving into a different life stage are extremely subtle and usually need to be confirmed with lab tests