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Mammalian target of rapamycin protein complex 2 regulates differentiation of th1 and th2 cell subsets via distinct signaling pathways

10.1016/j.actaastro.2013.04.013 158

NRF2, a master regulator of antioxidant gene expression, translocates to the nucleus upon phosphorylation and activates downstream targets such as heme oxygenase-1 (HO-1), SOD, and quinone oxidoreductase-1 (NQO1) (316)

The authors would like to thank the Deanship of Scientific Research at Majmaah University for supporting this work under Project Number No

Diet is an important modifiable risk factor for Alzheimers disease and dementia, as it is able to modulate structural brain connectivity, cause positive changes in brain function and behavior, and help regulate cognition and emotion [112,113]

Similar to our results, FOXO proteins were negatively regulated by the IGF1R/PI3K/AKT signalling cascade in breast cancer cells, human brain microvascular endothelial cell IRI, rat spontaneous intracerebral haemorrhage, or mouse cerebral IRI models 56,57,58,59