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However, accruing evidence points to multiple implications of these enzymes in cell signaling through MAPK and oncogene-activated protein kinase pathways, as well as programmed cell death, activation of immune cells, and stem cell differentiation (3)

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elegans homolog of MAPK phosphatase, LIP-1, behaves genetically as an inhibitor of MAPK activity and is likely to inactivate MPK-1 in germ cells (see Introduction) [21,23]
