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Variances in circadian phase, light responsiveness, and clock gene expression identified between older and younger adults [41], could lead to a different reaction to vitamin B12

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Tuna meal, which contains about 100 g of tuna, contains about 160% of the high nutritional value of vitamin B12

The MD for the 4 mg group was 0.81 (95% CI: 1.77 to 0.15, P = 0.10), with significant heterogeneity observed between studies ( P = 0.0001, I 2 = 94%)

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Vitamin B12 is a water-soluble vitamin essential to many key functions in the body
