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Convergent mechanismsoxidative stress, mitochondrial insufficiency, cellular senescence, immunosenescence with low-grade inflammation, and disrupted cholinergic/catecholaminergic signalingjointly depress tear volume and alter composition

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Meanwhile, 3-BP suppresses lactate production by inhibiting glycolysis, which not only repolarizes M2-type tumor-associated macrophages toward the M1 phenotypes and suppresses regulatory T cell (Treg) infiltration, but also alleviates cGAS lactylation to enhance cGAS activity and amplifying STING-mediated immune responses