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Sphingosine-1-phosphate lyase ( SGPL1 ), discoidin domain receptor tyrosine kinase 2 ( DDR2) , and VEGF were evaluated as proliferation, migration, and angiogenesis markers

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Immune effects are restorative, not overstimulating: It rebalances T-cell ratios, upregulates IL-2 in aged tissues, and improves neuroimmune integration, suggesting a targeted recalibration of immune tone rather than indiscriminate boosting. It restores circadian and hormonal rhythms: By stimulating melatonin synthesis, protecting pineal structure, and re-entraining clock genes, Epitalon may counter the widespread circadian drift of aging, with implications far beyond sleep, touching immunity, metabolism, and neuroprotection