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In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism
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The efficacy of adjunctive N-acetylcysteine in major depressive disorder: a double-blind, randomized, placebo-controlled trial
the resulting fatty acid oxidation produces ROS, which can bind mitochondrial proteins, resulting in mitochondrial ROS production and mitochondrial dysfunction [135]
doi: 10.3390/md9081419
Reszka KJ, O'Malley Y, McCormick ML, Denning GM, Britigan BE
