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Am J Physiol Endocrinol Metab (2005) 288(1):E1949.10.1152/ajpendo.00149.2004 177 NielsenCGormsenLCJessenNPedersenSBMollerNLundSet alGrowth hormone signaling in vivo in human muscle and adipose tissue: impact of insulin, substrate background, and growth hormone receptor blockade

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The mechanisms promoting drug resistance include the following: first, at the pharmacokinetic level, the overactivation of drug efflux pumps is mediated by ATP-binding cassette transporters (ABC transporters)

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Although increased catalase expression boosts resistance to oxidative stress, it also challenges iron regulation, adversely affecting fungal health in environments with limited iron [167]

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