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High concentrations of vitamin B12 may be due to underreporting supplement use, autoimmune disorders interfering with the B12 assay, or underlying renal or liver diseases

This immune activation occurs through multiple pathways including modulation of interleukin signaling and regulation of immune cell differentiation

10.1016/j.ccell.2018.03.004 125 ToumiR.SamerA.SoufliI.RafaH.Touil-BoukoffaC

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reported that CK-18 fragments were significantly elevated in the blood of MASH patients and served as an independent predictor of MASH, detecting the presence of MASH with over 90% specificity and an 80% negative predictive value [78]

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