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Most of the GhGPXs on expression in yeast can scavenge H 2 O 2

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BBB disruption mechanism(s) The primary function of the BBB endothelial cells is to form a protective barrier against particles/pathogens not to pass from the arterial blood into the cerebral extracellular fluid and reach the nerve tissues, so the BBB should be ensured without damage/harm [26]

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In hyperglycemia, increased glycolytic flux leads to an abundance of pyruvate entering the tricarboxylic acid (TCA) cycle, generating excess NADH and FADH 2 , which further supply electrons to the ETC and exacerbate the reduced state of its components

Image Descriptions Figure 17.3 image description: This diagram shows a negative feedback loop using the example of glucocorticoid regulation in the blood