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Description
TMAO has a high turnover rate, with more than 90% excreted in the urine after being metabolized by the kidney (49)
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These include enhancing intracellular TH availability via modulation of transporters such as monocarboxylate transporter 8 (MCT8) and deiodinases (e.g., DIO1), as well as directly targeting ECM remodeling through upregulation of MMP activity, inhibition of HA synthesis, and blockade of integrin-mediated signaling pathways (119121)
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Aunque el FMN o el FAD son tambin las formas naturales de la B2 (sobre todo en los productos lcteos), se suele obtener a partir de la produccin sinttica por motivos econmicos, ya que su aislamiento es muy complejo
