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Nature Aging , 1, 760777

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: L-lsoleucine (-) - (BCAA),

59, 60 The reason for suspecting CSCs in alternate angiogenesis and tumor resistance lies in their capabilities to produce much higher levels of VEGF in both anoxic and hypoxic environment than non-CSC population, 60 which perhaps might be boosting strong angiogenic cues after the relapse of VEGF blockade

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Just greater flexibility per preparation cycle