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Furthermore, ligands derived from the hexapeptide Ang IV but that are not proven to act as IRAP inhibitors have been reported

There can be significant discomfort associated with the testing methodology and findings in IC/BPS patients are inconsistent

The histidine imidazole and the N-terminal amine and lysine side chain give GHK a high intrinsic affinity for copper(II), and as the free apo-peptide it has been studied in preclinical and in vitro research as a copper-binding ligand and as a signaling molecule implicated in extracellular-matrix remodeling, collagen and metalloproteinase regulation, and antioxidant and anti-inflammatory gene-expression pathways

See also [edit] References [edit] 1 2 World Health Organization (2009)

doi: 10.3889/oamjms.2015.111

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