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ER activates autophagy, including the mTOR pathway and BNIP3 protein, promoting the degradation of cyclin D1 and controlling cell proliferation, thereby limiting tumor growth [107]

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In order to determine whether the metabolic changes observed in Tbx1 +/ mice were related to the vB12 pathway, we applied NMR-based metabolomic analysis to the four classes (treatments and genotypes), that is, PBS-treated WT and Tbx1 +/ mice and vB12-treated WT and Tbx1 +/ mice

Red horizontal line denotes median tag count in 1kb of a specific epigenetic mark at 0h after BDG exposure

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