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The sequence of events in microvesicle and nanovesicle formation and release illustrates that cellular aging as evident from increasing amounts of oxidized hemoglobin, aggregated band 3 protein and surface-bound IgG appears to induce an entrapment of these irreversible endproducts in lipid raft-containing microvesicles that are rapidly cleared

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DPP-4 is a major enzyme responsible for deactivating peptides [7]
