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B12 Deficiency and Joint Pain: Understanding the Link Whilst B12 supplementation itself does not typically cause joint pain, vitamin B12 deficiency can indeed contribute to musculoskeletal symptoms, creating a complex clinical picture

They also help the nervous system function properly

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B12 also downregulated CSF2 ( P = 0.0071) and CXCL10 ( P = 0.0205) in leukocytes from impaired individuals, although these genes were not differentially regulated when compared to the non-impaired group

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