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TNB-738 has also been shown to boost NAD + levels, making it a promising therapeutic option for metabolic and inflammatory diseases associated with NAD + deficiencies, including aging 156

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Author Contributions Mette JF Nielsen, Britt W Lauenborg and Viera Kupov contributed to the design, protocol and conduct of the studies

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MOTS-c treatment enhances physical capacity in old mice Aging is accompanied by a progressive decline in mitochondrial function 1,24 and loss of metabolic homeostasis, in which MOTS-c may play a role 2,10

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