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In this study, it was found that compounds R1R5 maintained over 70% cell viability even at the highest concentration tested (125 g/mL) (see Table 1)

doi: 10.3109/15563650.2016.1159309

For this reason, ongoing medical management, such as nasal steroids, saline irrigation, and allergy care, is sometimes needed to keep symptoms controlled over the long term

One of the challenges of expressing proteins in bacterial cells is solubility