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The truncation dramatically reduces binding to IGF binding proteins (IGFBPs), increases receptor affinity, and shortens half-lifecreating a potent, rapidly-acting growth factor with predominantly local rather than systemic effects when administered

: Potentiation of acetaminophen hepatotoxicity by alcohol
doi: 10.4103/0253-7176.106022 [DOI] [PMC free article] [PubMed] [Google Scholar]

doi: 10.4081/jbr.2021.9954
