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Recent work has also indicated that BSO can potentiate the toxicity of TMZ-induced bystander effect on glioblastoma cells 36 and a GSH transferase inhibitor was shown to potentiate the cytotoxic effect of TMZ in melanoma cells

G6PDH is classically regulated by NADPH/NADP + ratio ( G6PDH is essential for proper embryonic development and a complete absence of its activity can be lethal due to the high sensitivity of embryos to oxidative stress

Current human data are largely observational or derived from small-scale interventions, underscoring the need for cautious interpretation and further clinical validation

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Focusing on SIRT3, recent studies indicate that its activation is generally protective

To determine protein expression, a 3D region of interest (ROI) was drawn over the injected muscle and ipsilateral popliteal LN and the maximum standard uptake value (SUV max ) of [ 18 F]FP-TMP was quantified (Supplementary Fig