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Nevertheless, over the last twenty years there has been an increasing number of clinical studies evaluating nose-to-brain delivery as a novel option for the treatment of neurodegenerative and neurological diseases

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Formulas for V CGTL and V bCYSc (the transport of cysteine into the cell from the blood) appear in Additional File 1

The risk of alcohol dependence is higher in people with mental health conditions

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Due to the lower dielectric constant of lipidbased carriers compared to water, HIP stability is significantly increased in such systems