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A feedback loop is a regulatory mechanism in biological systems

Oxidative stress and treatment with many agents that activate Nrf2 act by modifying either Keap1 or Nrf2 posttranslationally to cause their dissociation [88,110]

To further determine whether miR-214 directly targets the promoter regions, a 1 kb promoter sequence upstream of the transcriptional start site of ACSL4 , SLC38A1 , and PRKAA2 was inserted into a pGL3-basic vector, respectively (Fig

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Furthermore, Chen et al