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Loss of tolerance of islet antigen-reactive B cells occurs early in disease and numbers of pancreatic CD20 + B cells correlate with -cell loss
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Nuhus PhD studentship was funded by a grant from Takeda UK Ltd
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Myeloid cells also express triggering receptor 1 (TREM-1), which reprograms macrophage metabolism, enhances glycolytic activity, activates the NLRP3 inflammasome, and triggers an inflammatory response in ALI (Zhong, 2023)
