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Finally, the oxidative stress and protein nitration causes the opening of the mitochondrial membrane transition pore (MPTP) leading to the collapse of the membrane potential and cessation of ATP synthesis, which is the cause of cell death [37, 38]

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The evidence for this approach is limited but growing

PMID: 18417119

Hcy is an indicator of methionine synthase (MS) activity and high Hcy levels can be an indicator of oxidative stress, which inhibits MS activity

The influence of methanol on mitochondrial function and oxidative stress parameters in the retina and optic nerve In vitro studies with the use of formate showed that inhibition of ATP production in cultures of photoreceptor cells (661 W) and RPE (ARPE-19) increases with a decrease in blood pH