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We believe that the available data shows that a lack of knowledge about GLP-1R agonists benefits among physicians has immensely affected their use in clinical practice

Indeed, administering GLP-1R agonists into the fourth ventricle in mice decreases food intake and body weight [21, 22], and GLP-1R knockdown in NTS neurons increases food intake [23, 23]

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Meta-analyses confirm robust effects on body composition, but variable functional outcomes, highlighting the importance of patient selection and concomitant exercise/nutritional strategies [65]

Mahindra MP, Jie M, Mapindra MP, Rehman S, Vaughan O, Hillman S, et al

41 It is not clear if the prevalence varies between type 1 and type 2 diabetes